Pharmacology & Dosage Calculation

Vitamin k dose in newborn?

Vitamin k dose in newborn?

  1. A 0.25 mg
  2. B 0.5mg
  3. C 1 mg Correct answer
  4. D 2mg

Explanation

Core Concept: Newborns have sterile intestines and lack the bacterial flora necessary to synthesize Vitamin K, placing them at high risk for Vitamin K Deficiency Bleeding (VKDB), also known as hemorrhagic disease of the newborn.

Clinical Presentation:

  • Bleeding from the umbilical stump, gastrointestinal tract, circumcision site, or intracranial hemorrhage.
  • Bruising and oozing from puncture sites.

Diagnosis:

  • First-line plan: Clinical assessment for bleeding and prolonged prothrombin time (PT).
  • Gold standard: Coagulation profile showing prolonged PT and normal platelet count, corrected by Vitamin K administration.

Management:

  • Acute: Prophylactic intramuscular (IM) injection of 0.5 to 1 mg of phytonadione (Vitamin K1) within the first hour of birth.
  • Long-term/Definitive: Monitoring for signs of bleeding, ensuring adequate breast milk or formula intake, and routine pediatric follow-up.

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